Revatis S.A. • Technologies Minimally invasive technology for obtaining pluripotent mesenchymal stem cells

Stem cells are truly pluripotent and exhibit exceptional paracrine properties

Adult stem cells are usually considered to have a limited potential for differentiation. Bone marrow and adipose tissue are the two most commonly used sources. Unfortunately, taking samples from these is more invasive, risky and painful.

Human health, Animal Health

Muscle microbiopsy

This is a minimally invasive procedure that uses a fine diameter (16G) biopsy needle. This allows the collection of 15 to 20 mg of tissue through a small skin puncture performed after local anesthesia and strict asepsis of the skin. The sample is placed in a specific medium, maintained between 4 and 8 degrees and sent to the production laboratory.

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Muscle microbiopsy

Human health, Animal Health

Cell culture

The micro-biopsies are sent to the laboratory within an ideal period of 48 to 72 hours, the samples are incubated in a specific culture medium. Progenitor cells develop from the biopsies. The fraction of interest is then isolated by centrifugation in a density gradient and amplified until the required number of cells is reached.

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Cell culture

Human health, Animal Health

Production in aseptic isolator

Stem cell production takes place in an aseptic isolator, the procedure, which involves a Quality Management System (QMS), and Electronic Batch Record (EBR) is compliant with GMP standards. This system can be transferred to other production units while guaranteeing identical production quality.

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Production in aseptic isolator

Intellectual properties and know-how

Revatis holds an exclusive license for all human and veterinary applications of a patent granted in many countries which protects the method of collecting and culturing stem cells. Support for continuing R&D programs has enabled Revatis to file for other patents thus strengthening its intellectual property rights.

mammalian muscle-derived stem cells

WO2015091210 A1

The present invention provides a new method of obtaining muscle-derived mesenchymal stem cells from microbiopsies of mammalian origin. The invention provides for a minimally invasive methodology yielding high amounts of MSCs that can differentiate into different cell lineages.

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New uses of mammalian muscle-derived stem cells

WO2018189121

The present invention relates to a method for assessing the effects of a compound or mixture on a mammal. This involves obtaining mammalian pluripotent muscle-derived mesenchymal stem cells or a population thereof, exposing them to the relevant compound or mixture and assessing the effects on the cells. This invention provides for a reliable assessment method applicable to drug development, toxicity testing and optimized personalized medicine.

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Method for obtaining differentiated cells from muscle-derived progenitor cells

WO2018189124

The present invention relates to a method for preparing differentiated mammalian cells collected by muscle microbiopsy, placing the sample in a cell culture medium, collecting and growing the cells and differentiating them in suitable differentiation medium.

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